There was a question at the info desk about when the first time the term PICO was coined, so the author could use the reference in a systematic review footnote. The usual reference for the birth of PICO seems to be this:
Sackett DL, Richardson WS, Rosenberg W, Haynes RB (1997). Evidence-based medicine: How to practice and teach EBM. New York: Churchill Livingston.
However, see http://jama.ama-assn.org/cgi/reprint/270/17/2093 for the first discussion of the ideas. The terms were then solidified in Richardson WS, Wilson MC, Nishikawa J, Hayward RS. "The Well Built Clinical question" ACP J Club. 1995 Nov-Dec;123(3):A12-3. The authors don't coin the acronym PICO but use all the words. (We don't have an online copy at U of T but someone on the web put up a scan here: http://www.mclibrary.duke.edu/subject/ebm/richardson.pdf )
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